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om E.c Aim iC BS Study the Diffusion of Solids in Liquids 1 om Introduction E.c When substances are brought in contact Équipe pro. 5, 22 January 2016 | Der Radiologe, Vol. 457-462. Menopausal status. MK enables differentiation and characterisation of breast lesions, providing new insights into microstructural complexity. In human breast tissue, an increase in ADC value following successful therapy has been observed in some studies. Aim The aim of this study was to investigate and evaluate the role of magnetic resonance (MR) diffusion kurtosis imaging (DKI) in characterizing breast lesions. A hypointense septumlike structure is seen within the tumor. As B0 increases, susceptibility artifacts can become more apparent and problematic. 189, No. Tumor cellularity is increased in malignant tumors, causing restriction of diffusion. Mastitis. 2, Australasian Physical & Engineering Sciences in Medicine, Vol. Once the source image quality is improved by implementation of noise reduction techniques, avoidance of artifacts and improvement of spatial resolution, signal analysis and feature extraction will yield the calculated tissue properties obtained from each voxel. This is best accomplished by identifying the lesion on diffusion-weighted images and then carefully placing a region of interest over the solid portion of the tumor to ensure that cystic or necrotic portions or normal breast parenchyma are not included in this region. The mass had an ADC value of 0.83 × 10−3 mm2/sec. 1039, American Journal of Roentgenology, Vol. However, the assessment of all these findings in combination indicates that diffusion-weighted imaging may have potential as an adjunct to conventional contrast-enhanced breast MR imaging. 12, No. 13, No. (c) Contrast-enhanced T1-weighted MR image obtained on day 2 of the menstrual cycle shows diffuse contrast enhancement in both breasts. 30, No. Peugeot 308 Active Pack Enjoy year round discount at Brest Auto Diffusion 16 rue Maupertuis 29200 Brest 02 98 42 12 91 Brest-auto-diffusion.com - - - #peugeot #308 #peugeot308 #voiture #car #berline #brest #finistere #bretagne #garage #newcar #peugeot308allure. These initial pilot tests performed on a small group of subjects are known as the proof of principle, to verify that the concept and related methods have the potential of being used before embarking on large-scale multicenter projects and clinical trials. The use of a small ROI placed on the darkest part of the lesion on the ADC map, avoiding necrotic, noisy … 69 Romain Faivre (Brest) wins a free kick on ... OM . When multiple averages are acquired, it is recommended that the individual images be reconstructed first so as to avoid any phase errors that may arise from patient motion. The desire to limit exposure to contrast agents is increasing because of a growing awareness of nephrogenic systemic fibrosis; however, as discussed earlier, diffusion-weighted imaging findings cannot be assessed in isolation from findings obtained with other MR imaging sequences (eg, T2-weighted imaging) because diffusion-weighted imaging has a low specificity for breast cancer and a low sensitivity for the detection of DCIS. Baseline ADC does not seem to predict response in all tumor subtypes and the usefulness of this parameter pre-treatment is not clear.86–88, Residual disease evaluation. The high intrinsic contrast achieved with DWI without the injection of external agents and the ease of implementation into multiparametric protocols due to the fact that it is an inexpensive and fast sequence has triggered several studies on the role of DWI as an alternative to DCE for breast cancer screening. 3, The Egyptian Journal of Radiology and Nuclear Medicine, Vol. In these studies, the influence of epidemiological data (sex, age, physiological status) and genuine biological variations has to be studied.2, 1. 3, No. 3, The British Journal of Radiology, Vol. Methods Sixty-four subjects with breast … 16, No. ADC values can be influenced by which b-values are applied, a fact that highlights the need for consistent and standardized protocols. The best pictures of the game between OM and Brest. 5. Precise measurement of ADC is important since the dynamic range of the biomarker is quite small, from approximately 0.5 × 10−3 mm2/s in densely packed cells to 3.0 × 10−3 mm2/s in fluid-filled cysts.24, Technical validations of DWI are performed using different measurements related to image acquisition, processing, analysis and ADC measurements These measurements are done with phantoms and in healthy volunteers or in patients24,25, Biological validation shows the link to tumor biology and is the correlation between preclinical disease models or human studies and reference methods such as histopathology, immunohistochemistry or genomics. The reduced ADC value in week 2 of the menstrual cycle is thought to correlate with reduced water content in the breast during this time (53,54). 1, Iranian Journal of Radiology, Vol. Pereira et al (41) analyzed the ADC values of benign and malignant breast tumors with various combinations of b values (0, 250, 500, 750, and 1000 sec/mm2). Background: Physicians who provide primary care to women have the opportunity to identify patients at high risk for breast cancer who are candidates for risk reduction strategies. The ADC describes the average area occupied by a water molecule per unit time (mm2/s) and as a reference point, the ADC value of free water molecules at 37°C is 3.0 × 10−3 mm2/s. 3, 16 September 2012 | European Radiology, Vol. The main objective of radiomics is the discovery of signatures (imaging biomarkers) which have strong associations with patient’s prognoses or tumor subtype classification. 11, 31 October 2016 | European Radiology, Vol. Lorient et Brest font partie des mauvais élèves au niveau défensif : le FCL est 19e défense de Ligue 1 (54 buts concédés), Brest 18e (53). 6, The Egyptian Journal of Radiology and Nuclear Medicine, Vol. Diffusion is the process of random motion of water molecules in a free medium. Le coup d’envoi et la diffusion Reims Marseille OM comptant pour le championnat "Ligue 1" (saison 2018-2019) sera donné vendredi 23 avril 2021 à 21:00. 5, The British Journal of Radiology, Vol. 39, No. Abstract . In general, determination of ADC is performed by acquiring images at two b-values and fitting the corresponding signal intensities into a monoexponential model. The most significant advantage of diffusion-weighted imaging over contrast-enhanced MR imaging is its high sensitivity in the detection of breast cancer without contrast material injection. For DWI acquired with two or more different. The stepwise development of imaging biomarkers, provides an orderly framework within which to discuss the technique of DWI, as well as its clinical applications and its validation as an imaging biomarker (Figure 1). Future applications of DWI in screening, DWI modeling and radiomics are also discussed. 01, World Journal of Radiology, Vol. This study aimed to pool all published results to provide more robust evidence of the differential diagnosis between malignant and … (c) On an ADC map, the left-sided mass (arrowheads) has an ADC value of 1.65 × 10−3 mm2/sec, and the right-sided mass (arrows) has an ADC value of 1.52 × 10−3 mm2/sec. 40, No. The signal of breast parenchyma is usually suppressed when diffusion-weighted images are acquired at high b values (1000–1500 sec/mm2). Petsatodis E, Kiropoulos A, Papachristodoulou A, Anastasiadou K, Voultsinou D, Palladas P. Connected authors. 23, No. Both masses have smooth margins. (c) ADC map shows the mass with an ADC value of 1.82 × 10−3 mm2/sec. Small cancer foci, including DCIS and scattered foci of invasive lobular cancer, may not be depicted at diffusion-weighted imaging. Parallel imaging shortens acquisition times and minimizes these artifacts, ultimately leading to decreased image distortion (but also reduces SNR). (b) On a diffusion-weighted image obtained at b = 1000 sec/mm2 (spin-echo echoplanar imaging, TR/TE = 9800/77.6, bandwidth = ±250 kHz, FOV aspect ratio = 0.8 [340 × 272], matrix = 160 × 192, section thickness = 5 mm, no intersection gap, SSRF prepulse without ASSET), the signal intensities of the DCIS (arrow) and normal breast parenchyma are almost equivalent. (b) On a diffusion-weighted image obtained at b = 1500 sec/mm2 (spin-echo echoplanar imaging, TR/TE = 7800/88.4, bandwidth = ±250 kHz, FOV = 340 mm, matrix = 160 × 192, section thickness = 5 mm, no intersection gap, SSRF prepulse with ASSET), the mass has high signal intensity with marginal spiculation and a central hypointense area. Its diagnosis will remain problematic even with the combined use of ADC value, signal intensity, and morphologic features. Residual disease has traditionally been evaluated with DCE-MRI and meta-analyses comparing both techniques have shown that DWI adds sensitivity for predicting pCR to the high specificity of DCE-MRI for residual disease.89 Both techniques combined achieve the best diagnostic accuracy.50 A recent meta-analysis focusing solely on DWI90 revealed a pooled sensitivity of 0.89 and a specificity of 0.72 for detecting pCR. IDC with central necrosis. 15, No. These changes cause an increase in the mobility of water in the damaged tissue, which is reflected in the increase in ADC value. The parameters of diffusion-weighted imaging need to be standardized to allow comparison of multicenter studies and assessment of the clinical utility of diffusion-weighted imaging findings and ADC values obtained in the breast. Early studies with mice80 showed that increased diffusivity could be shown within days of therapy onset in implanted breast cancers. Welkom in de Cité du Ponant! Breast Cancer.—Because of their higher cellularity, the majority of invasive ductal carcinomas (IDCs) demonstrate higher signal intensity and lower ADC values than do benign tumors and normal breast parenchyma on diffusion-weighted images. Er is gratis WiFi beschikbaar. The faster a molecule diffuses, the greater the attenuation after applying the diffusion gradients and the weaker the corresponding pixel signal intensity at DWI. 7, 22 March 2017 | NMR in Biomedicine, Vol. The observed ADC value depends on many factors: fluid viscosity, membrane permeability, water transport mechanisms and the microstructure of the compartment containing diffusing water. Dom Fani Braverman, Brest: Bekijk 121 onpartijdige beoordelingen van Dom Fani Braverman, gewaardeerd als 4,5 van 5 bij Tripadvisor en als nr. The magnetic susceptibility artifact, due to magnetic field inhomogeneities, can cause severe image distortions at the interface of materials with different magnetic susceptibilities such as the air/tissue or adipose/glandular tissue interfaces. Evangelos Petsatodis GREECE Patient. In such cases, an ADC map may be useful for distinguishing between normal breast parenchyma and malignant tumor. Om deze reden heeft het fort na de oorlog een ‘heldenstatus’ gekregen en is Brest hierom in heel Rusland beroemd. Accordingly, ADC value may provide an earlier biomarker for tumor response than changes in tumor size. (a) Contrast-enhanced T1-weighted MR image (VIBRANT, TR/TE = 7.1/3.4, flip angle = 12°, bandwidth = ±41.7 kHz, FOV = 360 mm, matrix = 400 × 400, section thickness = 0.9 mm, no intersection gap, SpecIR with ASSET) shows bilateral segmental enhancement representing DCIS in the left breast (arrows) and fibrocystic disease in the right breast (arrowheads). 18, No. Diffusion-weighted imaging (DWI) of the breast is a MRI sequence that shows several advantages when compared to the dynamic contrast-enhanced sequence: it does not need intravenous contrast, it is relatively quick and easy to implement (artifacts notwithstanding). 84, No. (b) Diffusion-weighted image obtained at b = 1000 sec/mm2 (spin-echo echoplanar imaging, TR/TE = 9800/77.6, bandwidth = ±250 kHz, FOV aspect ratio = 0.8 [340 × 272], matrix = 160 × 192, section thickness = 5 mm, no intersection gap, SSRF prepulse without ASSET) shows corresponding hyperintense lesions. All diffusion coefficients were significantly higher in the normal tissue than in malignant lesions . In this review, the current applications of DWI for lesion characterization and prognosis as well as for response evaluation are analyzed from the point of view of the necessary steps to become a useful surrogate of underlying biological processes (tissue architecture and cellularity): from the proof of concept, to the proof of mechanism, the proof of principle and finally the proof of effectiveness. 30, No. 1, 30 January 2015 | Acta Radiologica, Vol. In large fibroadenomas, a low-signal-intensity septum may be observed on diffusion-weighted images. 23, No. Although initial studies posited increased ADC values during the second half of the menstrual cycle,7,31 these variations were non-statistically significant and subsequent studies confirmed no influence of the menstrual cycle32–35 or background parenchymal enhancement36–39 on ADC values. To confirm these results, further investigation in a broader sample should be performed. 1, Journal of Korean Medical Science, Vol. However, the detection of DCIS may be difficult on ADC maps alone. Commentary on: diffusion-weighted imaging evaluation across different platforms: why is reproducibility essential in medical imaging? (a) Contrast-enhanced T1-weighted MR image (VIBRANT, TR/TE = 6.5/3.1, flip angle = 12°, bandwidth = ±41.7 kHz, FOV = 360 mm, matrix = 360 × 360, section thickness = 0.9 mm, no intersection gap, SpecIR with ASSET) shows segmental enhancement in the left breast (arrow), a finding that is compatible with DCIS. The ADC value of breast tissue is higher on day 2 (2.26 × 10−3 mm2/sec) than on day 22 (1.87 × 10−3 mm2/sec). 3, Magnetic Resonance Imaging, Vol. In tissues with long relaxation times, the strong T2 signal maybe mistaken for restricted diffusion, a phenomenon known as the T2 shine-through effect.11,12, To be clinically useful, a biomarker needs to undergo validation (performance of the test) and qualification (clinical approval) in order to ensure that the obtained measurements have a precise relationship with the underlying biological reality.2 Several validations including technical, biological and clinical have to be conducted before a biomarker is introduced in clinical research. 3, International Journal of Research -GRANTHAALAYAH, Vol. Europe, Brest. In clinical imaging, the sequence used is a T2 weighted spin-echo sequence with two motion-probing gradients next to the 180° refocusing pulse.7 where segmented or single shot echoplanar readout techniques (EPI) are used to accelerate data acquisition. 27, No. The range includes polyester diffusion filters, frosts, flexi-frosts, perforated diffusion, grid cloths and spun materials all in different densities for a wide range of lighting effects. De Slag om Białystok-Minsk was een onderdeel van Operatie Barbarossa, de Duitse inval in de Sovjet-Unie.Op 22 juni 1941 brak de Duitse Wehrmacht in de centrale sector van het front door de grensverdediging, rukte op naar Minsk en omsingelde drie legers van het Rode Leger.Alle Sovjet-tegenaanvallen werden afgeslagen en Minsk viel in handen van de Duitse Wehrmacht, waarbij meer … Diffusion-weighted imaging reflects variable cellularity and stromal density present in breast fibroadenomas, Role of diffusion weighted imaging and dynamic contrast enhanced MR mammography to detect recurrence in breast cancer patients after surgery, Intravoxel incoherent motion diffusion-weighted MR imaging of breast cancer: association with histopathological features and subtypes, Performance of DWI as a Rapid Unenhanced Technique for Detecting Mammographically Occult Breast Cancer in Elevated-Risk Women With Dense Breasts, Diffusion-weighted imaging and
High-resolution diffusion-weighted imaging can display the morphologic features of the tumor, which may be helpful for interpretation (Fig 10). higher density of cells) will show a higher signal than regions with fast water mobility. Hier volgt de top 10 van leukste dingen om te doen in Brest… Thus, regions with restricted diffusion (i.e. Multiple cysts. DWI is used to visualize the degree of water molecule diffusion at in vivo MR imaging. At a higher b value, the signal intensity of mucinous carcinoma will decrease at diffusion-weighted imaging due to T2 shine-through. 2S, Asian Pacific Journal of Cancer Prevention, Vol. 3, Magnetic Resonance Imaging, Vol. Matsuoka et al (76) demonstrated a greater visibility of tumors less than 10 mm at 3.0 T than at 1.5 T, but no difference in visibility for tumors greater than 10 mm. Tips; Brest Auto Diffusion. Low spatial resolution is a limitation of DWI that can be overcome by a higher SNR, afforded by higher magnetic field strength MR units. The higher magnetic field strength results in an increase in chemical shift artifact, susceptibility artifact, and B1 and B0 inhomogeneity, which can cause image distortion and inhomogeneous fat suppression (75). 87, No. Figure 23 Graph illustrates changes in the ADC value of various pathologic conditions of the breast 10 minutes after the injection of gadopentetate dimeglumine. Raadsleden Coevorden bezochten zusterstad Brest: Alle vooroordelen over Wit-Rusland kloppen (en waag het niet om te lachen om de president en zijn bodybuilders) Diffusion in breast lesions follows a non-Gaussian distribution. 9, No. The hypointense lesion (black arrow) shows noise, a finding that was thought to result from hemosiderin deposition. 2021 World Rowing European Olympic and Paralympic ... ... null (b) On a diffusion-weighted image obtained at b = 1500 sec/mm2 (TR/TE = 9800/85.3), the cyst that was hyperintense in a retains much of its high signal intensity (arrowhead), whereas the other two cysts demonstrate marked loss of signal intensity (arrows). Whole-Brain Functional and Diffusion Tensor MRI in Human Participants with Metallic Orthodontic Braces, Introductions of Current and New Breast Diffusion MRI Techniques: Potential Alternative to Contrast-enhanced MRI Technique, Diffusion-weighted TSE-based MRI at 3T Magnets: Body Applications, Difficult Water Imaging? Moreover, there is currently no standard ADC value for each breast disease because there is no consensus on an accepted range of b values for diffusion-weighted imaging. These results have been confirmed in another study conducted at 3.0 T (78), in which ADC values were found to be the same at 1.5 T and 3 T, a finding that is consistent with the premise that ADC values are independent of field strength (76). 28, No. Use of a spin-echo–based sequence, high imaging bandwidth, and short TE can reduce the impact from this artifact. Several studies suggest the diagnostic assessment of diffusion-weighted images in combination with the assessment of signal intensity and lesion morphologic features on T2-weighted images (27,30). 90, No. Several recent studies have shown the potential of diffusion-weighted imaging in helping predict the effect of neoadjuvant chemotherapy (38,48,64–66). Diffusion Weighted Imaging (DWI) is now widely used as an important addition to standard breast MRI protocol to improve specificity and avoid unnecessary biopsies in benign enhancing breast lesions [ 3, 4 ]. Tozaki and Fukuma (37) reported eight false-negative cases of non-mass-forming DCIS. Translated +4. 8, No. C. Sahin, E. AribalThe role of apparent diffusion coefficient values in the differential diagnosis of breast lesions in diffusion-weighted MRI. Published by the British Institute of Radiology, The development and validation of diffusion-MRI as an imaging biomarker, Biomarker validations. 1, Journal of Magnetic Resonance Imaging, Vol. This finding was attributed to the increased SNR afforded by the increase in magnetic field strength. View icbse.com-727.pdf from CHEMISTRY 12 at University of the Fraser Valley. (a) Contrast-enhanced T1-weighted MR image (VIBRANT, TR/TE = 6.5/3.1, flip angle = 12°, bandwidth = ±41.7 kHz, FOV = 360 mm, matrix = 350 × 350, section thickness = 0.9 mm, no intersection gap, SpecIR with ASSET) shows a spiculated mass with peripheral enhancement. Intravenous contrast. Potential areas of growth include detection with DWI without contrast agents, investigation of additional biological properties through DWI modeling and analysis of radiomics classifiers in order to better stratify patients and enable a real precision medicine. It is likely that diffusion-weighted breast imaging will be shown to have a supportive role in breast MR imaging. If diffusion-weighted breast imaging proves useful in the clinical setting, it promises to improve the accuracy of breast MR imaging. (b) Diffusion-weighted image obtained at b = 1500 sec/mm2 (spin-echo echoplanar imaging, TR/TE = 7800/88.4, bandwidth = ±250 kHz, FOV = 340 mm, matrix = 160 × 192, section thickness = 5 mm, no intersection gap, SSRF prepulse with ASSET) shows the mass with peripheral high signal intensity (arrow) and central low signal intensity (arrowhead). Mucinous carcinoma. Given the time constraints of clinical practice, analysis of an ADC value with two b values may be considered reasonable and acceptable. Fibroadenoma with myxomatous change. In clinical practice, physical examination findings should be considered when assessing these entities, thereby simplifying the radiologic diagnosis. *b = 1500 sec/mm2. DWI is used to visualize the degree of water molecule diffusion at, The first step in the proof of mechanism of an imaging biomarker is the, In clinical imaging, the sequence used is a, The ADC describes the average area occupied by a water molecule per unit time (mm, The observed ADC value depends on many factors: fluid viscosity, membrane permeability, water transport mechanisms and the microstructure of the compartment containing diffusing water. The EUSOBI consensus statement9 recommends performing DWI before DCE-MRI and consistency in timing across examinations is also advocated.11. 85, No. However, the signal intensity of DCIS with low cellularity (eg, low-grade DCIS) may be ambiguous, especially at higher b values, due to signal decay resulting from the use of higher diffusion gradients. reproducibility, Comparison of image quality and application values on different field-of-view diffusion-weighted imaging of breast cancer, The utility of diffusion weighted MRI and apparent diffusion coefficient in characterization of breast masses, Comparison of fitting methods and b-value sampling strategies for intravoxel incoherent motion in breast cancer, Role of quantitative diffusion weighted imaging in characterization of breast masses, Diffusion weighted images of metastatic as compared with nonmetastatic axillary lymph nodes in patients with newly diagnosed breast cancer, Fat suppression techniques (STIR vs. SPAIR) on diffusion-weighted imaging of breast lesions at 3.0 T: preliminary experience, Two cases of primary small cell carcinoma of the breast showing non-mass-like pattern on diagnostic imaging and histopathology, Utilisation of MR spectroscopy and diffusion weighted imaging in predicting and monitoring of breast cancer response to chemotherapy, Differentiation between Graves' disease and painless thyroiditis by diffusion-weighted imaging, thyroid iodine uptake, thyroid scintigraphy and serum parameters, Diffusion Weighted Imaging and Apparent Diffusion Coefficient in 3 Tesla Magnetic Resonance Imaging of Breast Lesions. Hospital Universitario de la Ribera, The stepwise development of imaging biomarkers, provides an orderly framework within which to discuss the technique of DWI, as well as its clinical applications and its validation as an imaging biomarker (. Tot de overige faciliteiten van Dom na Berezovke behoort een terras. An inter- and intra-reader agreement study, Quality assurance multicenter comparison of different Mr scanners for quantitative diffusion-weighted imaging, Implementing diffusion-weighted MRI for body imaging in prospective multicentre trials: current considerations and future perspectives, Diffusion-weighted magnetic resonance imaging as a cancer biomarker: consensus and recommendations, Quantitative diffusion imaging in implanted human breast tumors, Differentiation of clinically benign and malignant breast lesions using diffusion-weighted imaging, Relation between cancer cellularity and apparent diffusion coefficient values using diffusion-weighted magnetic resonance imaging in breast cancer, Apparent diffusion coefficient in invasive ductal breast carcinoma: correlation with detailed histologic features and the enhancement ratio on dynamic contrast-enhanced MR images, Correlation of tumor characteristics derived from DCE-MRI and DW-MRI with histology in murine models of breast cancer, Menstrual cycle variation of apparent diffusion coefficients measured in the normal breast using MRI, Diffusion weighted imaging of the normal breast: reproducibility of apparent diffusion coefficient measurements and variation with menstrual cycle and menopausal status, Apparent diffusion coefficient of breast cancer and normal fibroglandular tissue in diffusion-weighted imaging: the effects of menstrual cycle and menopausal status, Diffusion-tensor MR imaging of the breast: hormonal regulation, Effect of menstrual cycle and menopausal status on apparent diffusion coefficient values and detectability of invasive ductal carcinoma on diffusion-weighted MRI, Diffusion-weighted MRI: association between patient characteristics and apparent diffusion coefficients of normal breast fibroglandular tissue at 3 T, Impact of fibroglandular tissue and background parenchymal enhancement on diffusion weighted imaging of breast lesions, Comparison of contrast enhancement and diffusion-weighted magnetic resonance imaging in healthy and cancerous breast tissue, Diffusion tensor imaging in the normal breast: influences of fibroglandular tissue composition and background parenchymal enhancement, Characterization of malignant breast tissue of breast cancer patients and the normal breast tissue of healthy lactating women volunteers using diffusion MRI and in vivo (1) H MR spectroscopy, Apparent diffusion coefficient mapping using diffusion-weighted MRI: impact of background parenchymal enhancement, amount of fibroglandular tissue and menopausal status on breast cancer diagnosis, Microperfusion-induced elevation of ADC is suppressed after contrast in breast carcinoma, Comment on ADC reductions in postcontrast breast tumors, Diffusion-weighted MR imaging of benign and malignant breast lesions before and after contrast enhancement, Effect of gadolinium injection on diffusion-weighted imaging with background body signal suppression (DWIBS) imaging of breast lesions, Diffusion-weighted imaging: effects of intravascular contrast agents on apparent diffusion coefficient measures of breast malignancies at 3 tesla, Effect of B value and pre-admission of contrast on diagnostic accuracy of 1.5-T breast DWI: a systematic review and meta-analysis, Meta-analysis of quantitative diffusion-weighted MR imaging in the differential diagnosis of breast lesions, Magnetic resonance (MR) differential diagnosis of breast tumors using apparent diffusion coefficient (ADC) on 1.5-T, Accuracy of combined dynamic contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging for breast cancer detection: a meta-analysis, Quantitative diffusion weighted imaging for differentiation of benign and malignant breast lesions: the influence of the choice of b-values, Breast lesions: diagnosis using diffusion weighted imaging at 1.5T and 3.0T-Systematic review and meta-analysis, MR mammography using diffusion-weighted imaging in evaluating breast cancer: a correlation with proliferation index, Dynamic contrast-enhanced and diffusion-weighted MRI of estrogen receptor-positive invasive breast cancers: associations between quantitative MR parameters and Ki-67 proliferation status, Quantitative apparent diffusion coefficient as a noninvasive imaging biomarker for the differentiation of invasive breast cancer and ductal carcinoma in situ, Diffusion weighted MR imaging of breast and correlation of prognostic factors in breast cancer, Quantitative apparent diffusion coefficient measurement obtained by 3.0Tesla MRI as a potential noninvasive marker of tumor aggressiveness in breast cancer, Can diffusion-weighted imaging predict tumor grade and expression of Ki-67 in breast cancer?